RIC MASTEN
DATES, BLOOD MARKERS, & CORRESPONDING TREATMENTS & MEDICATIONS

TREATMENTS Yellow= PC SPES, SPES — Aqua= Taxotere (chemo) — Pink= 3DRT (radiation), DES= green
Date
PSA
CEA
PAP
 Prolactin
Medications & TreatmentColor
02/11/98 - 5 -- -- -- first known PSA test
O3/19/99 > 70 - - - -
04/06/99 > 81 - - - begin ADT1 Casodex) 50 mg/d
04/12/99 -- - - - Color Bilateral Orchiectomy
05/07/99 < 7.3 - - - -
07/09/99 < 0.2 - - - -
10/01/99 - 0.2 - - Color - -
01/07/00 > 6.23 - - - -
01/20/00 > 6.81 - - - -
02/08/00 > 8.08 - - - - d/c'd Casodex
02/14/00 > 11.08 - - - begin PC SPES 9/day — Begin Vegan diet
03/16/00 < 4.8 - - -
07/05/00 -- -- - - begin Vioxx: 25 mg/day for met right pain in groin
07/17/00 - - - - begin Aredia: 90 mg IV every 3 wks.
08/03/00 > 2.01 --- -- -- up PC SPES dose to 13/day
09/14/00 > 3.05 - > 6.8 - --
11/02/00 > 6.20 - > 823 - -
11/10/00 - - - Color - Color add SPES 4/day
11/27/00 < 6.6 > 840.05 >12.07 -- also tested NSE 3.6, CGA 9.1
02/07/01 < 1.53 > 898.05 - - Color -
02/26/011 < 1.53 < 760.17 >20.07 - -
03/05/01 - - - - begin Taxotere 25 mg/m2, Decadron (10 mg)
03/17/01 - - - - begin Rocaltrol 0.5 mcg 1/day Calcium 1000 mg/day
03/25/01 - - - - begin Potassium Fluoride 4 drops/day
03/25/01 - - - - d/c'd Vioxx -- blood in right eye
04/09/01 < 1.39 < 481.0 < 4.09 > 13. --
05/14/01 < 0.82 < 474.6 < 2.60 - -
05/21/01 - - - - d/c'd Taxotere 25 mg/m2, Decadron d/c'd - just during RT
05/24/01 - - - - begin 3DRT dose 50.4 gy - 5&i/2 wks
06/01/01 - - - -- begin Dostinex: 0.5 mg 2/wk
06/28/01 < 0.49 > 616.0 < 2.60 - --
07/05/01 - - - - end 3DRT - 28 sessions over
07/16/01 - - - - resume Taxotere 25 mg/m2, Decadron (10 mg)
07/27/01 - - - - begin Coumadin 1/2 mg /day
07/30/01 < 0.19 < 536.1 < 1.2 - -
08/20/01 < 0.11 < 514.4 < 1.1 - -
09/17/01 < 0.06 < 339.8 > 1.6 < 2. < 1.2
10/22/01 < 0.05 < 232.6 - - -
12/03/01 < 0.03 < 123.5 < 0.9 - -
01/02/02 - 0.03 < 68.6 > 1.2 - -
01/14/02 - 0.03 < 62.5 — 1.2 -x -
02/18/02 > 0.04 < 42.8 < 0.9 x INR: 1.11 increase Coumadin 2 mg /day
04/08/02 x x x < 1. x
05/13/02 > 0.05 < 22.3 > 1.3 x d/c'd PC SPES & SPES
05/28/02 < 0.04 < 18.5 < 1.0 x x
07/15/02 > 0.05 < 9.7 < 1.0 x d/c'd Taxotere 25 mg/m2, d/c'd - vacation 4/w
07/17/02 x x xx x begin low dose DES 3mil/day, Decadron 2mil/day for sciatic.
10/17/02 < 0.03 < 5.6 - 1.0 x
11/11/02 > 0.05 > CEA 6.8 resume Taxotere 25mg/M2 , Decadron 4mg/3 wks-1wk off - start
11/11/02 d/c'd Low Dose DES 3 mg/day
11/25/02 <0.04 <5.7 < 0.3 Deoxypyridinol 4.5, Creatinine 0.23
2/8/03 . . . . d/c”d Taxotere 25mg/M2 , Decadron 4mg/
2/10/03 <0.04 <5.7 -0.3 begin 400mg/d Celebrex
4/15/03 >0.08 <4.7 >1.0
5/20/03 >0.14 >6.5 >1.1
5/27/02 . . . . resume Low Dose DES 3 mmg/day,
6/17/03 <0.13 >7.0 >1.4
x x x x
-RIC'S GENERAL DIGEST

Richard Masten, 76; 2/11/98 PSA 5 going up to > 70 on 3/19/99;
Dx#1 3/19/99, bPSA > 81, GS 8, BS 4/99: pelvic bone x 5 mets (EOD 1).
Rx1: ADT1 (Casodex) 4/6/99: 50 mg/d
Rx2: Orchiectomy 4/12/99: PSA < 7.3 (5/7/99); 7/9/99 & 10/1/99 = < 0.2; PSA > 6.23 by 1/7/00.
BS #2 1/13/00 with 2 new bone lesions (pelvis + base of spine). Testo: ?, PSA > to 6.81 on 1/20/00
Rx3: Casodex d/c'd (2/8/00): PSA > 8.08
Rx4: PC SPES (2/9/00): bPSA > 11.08, 9/day,
Begin Vegan diet & Bob Beck zapper 1 1/2 hr/day; PSA < 4.8 (3/16/00), < 2.31 (5/11/00), < 1.42 (6/30/00);
Rx2 Vioxx25mg/day for groin pain (6/30/00)
Rx5: Begin Ipriflavone 200mg/day 7/5/00: zapper d/c'd 7/7/00,
Rx6: Aredia 7/17/00: 90mg q 3 wks
PSA < 2.01 (8/3/00), increase PC SPES 12/day, resume zapper,
PSA > 3.05, PAP > 6.8 (9/14/00), increase PC SPES 13/day
PSA > 6.20 (11/2/00), CEA > 823. (11/2/00)
Rx7 Add 4/day SPES (11/10/00)
PSA < 6.6, PAP > 12.7, CEA > 840.5, CGA 9.1, NSE 3.6 (11/27/00
Dx#2 BS #3 no new lesions (pelvis a bit more active) (12/7/00)
Dx#3 CT (chest, adb &pelvis) clean (12/7/00) PSA < 2.03, CEA > 898.8, Ferritin 144.
Dx#4 CEA scan - negative (2/12/01)
Dx#5 Colonoscopy - clean (2/15/01)
Dx#6 Prostacint scan - uptake in all old leisons (2/16/01)
PSA < 1.53, CEA < 760.17, PAP > 20,07, (2/26/01)
Rx8 Taxotere 25mg/M2, Decadron (10mg) (3/5/01) every Monday
Rx9 Begin Rocaltrol now changed to Calcitirol 0.5mcg 1/day (3/17/01)
Rx10 Begin Potassium Flouride 2drops/day (3/25/01)
PSA < 1.39, CEA < 481., PAP < 5.9, Prolactin 13., (4/09/01)
Rx11 Vioxx d/c'd 4/25/2001
PSA < 0.82, CEA < 474.6, PAP < 2.60, (5/14/01)
Rx12 Begin 3DRT (5/24/01) Dose: 50.4 gy -- Ports: AP/PA/LAO/RPO - 5 1/2 weeks.
Rx12 Taxotere 25mg/M2, Decadron d/c'd 5/21/01 for 8 weeks
Rx13 Dostinex 6/1/01 0.5mg 2/wk. -- Starting dose - 0.25mg for 2 wks.)
PSA < 0.49. CEA > 616.0, PAP < 2.5, (6/28/01)
Rx14 Taxotere 25mg/M2, Decadron (10mg) -- resume (7/16/01)
PSA < 0.19. CEA < 536.1, PAP < 1.2 (7/30/01)
Rx15 Coumadin 1/2 mg/day (7/27/01),
Dx#7 Protime 11.2, INR 1.09 (8/6/01)
PSA < 0.11. CEA < 415.4, PAP < 1.1 (8/20/01), Prolactin < 2, (8/28/01)
PSA < 0.06. CEA < 339.8, PAP >1.6 (9/17/01)
Dx#8 BS #4 stable metastatic disease (decrease in degree of activity) (09/18/01)
PSA < 0.05, CEA < 232.5, < PAP 1.2 (10/22/01)
Rx 16 Rocaltrol now changed to Calcitirol 0.5mcg 1/day (3/17/01)
PSA < 0.03, CEA < 123.5, - PAP 0.9 (12/03/01)
PSA - 0.03, < CEA < 68.6,- PAP< 0.9 (01/02/02)
PSA > 0.04, <CEA <42.8, PAP<0.9, INR 1.11 (02/18/02)
Rx17 Increase Coumadin 1mg/day
Dx #9 AP pelvis (no fracture but extensive metastatic blastic lesion - rt. Hemipelvis. (0/3/27/02
Dx #10 MRI of lumbar spine Does not reveal evidence of metastatic disease (4/7/02)
Dx #11 Bone Scan disease in the rt. Ischiopubic has diminished and is somewhat improved. (04/10/02)
Rx #18 PC SPES & SPES d/c'd PSA > 0.05, CEA <22.3, PAP >1.3 (05/13/02)
PSA <0.04, CEA <18.5, PAP <1.0 (05/28/02)
PSA >0.05, CEA <9.7, PAP –1.0 (07/17/02)
Rx #19 Taxotere 25mg/M2, 4 week vacation, Decadron 2mil/day for sciatic pain - (07/15/02)
Rx #20 Low Dose DES 3 mil/day (07/17/02)
PSA <0.03, CEA <5.6, PAP 1.3, NSE 15.6, CGA 22.0, Testosterone 17, INR 11.2, Prolactin 1.0 (10/16/02)
Dx #8 Bone Scan uptake in the right ischiopubic bones has increased in intensity and extent. uptake in
the mid-lumbar spine appear unchanged, Activity is present in the kidneys and bladder.
Rx #22 d/c'd Low Dose DES 3 mg/day. NSE 3.9 (11/11/02)
Rx #21 resume Taxotere 25mg/M2 , Decadron 4mg/3 wks-1wk off - start (11/11/02)
PSA >0.05, > CEA >6.8. (11/18/02)
Deoxypyridinol 4.5, Creatinine 0.23 (11/25/02)
Rx #24 d/c”d Taxotere 25mg/M2 , Decadron 4mg/3 (2/8/03)
PSA <0.04. <CEA 5.7, <PAP 0.3 (2/10/03) begin 400mg/d Celebrex (3/19/03)
PSA >0.08, <CEA 4.7, >PAP 1.0 (4/15/03)
PSA >0.14, >CEA >6.5, PAP – >1.1 (5/20/03) resume Low Dose DES 3 mmg/day, (5/27/03)
PSA >0.13, >CEA >7.0, PAP – >1.4 (6/17/03)
PSA 0.13, CEA 6.6 PAP –0.9 d/c'd Low Dose DES 3 mg/day 07/29/03
PSA 0.50, CEA 10.5, PAP 1.0 09/29/03
resume Low Dose DES 3 mg/day 10/06/03
PSA 0.23, CEA 12.2, PAP 1.6 resume Celexa 20mg. D/c'd DES 3mg/d, Warfarin 2mg 11/10/03
resume Celexa 20mg. D/c'd DES 3mg/d, Warfarin 2mg 11/13/03
resume Low Dose DES 3 mg/day, Warfarin 2mg 12/22/03
PSA 0.72, CEA 12.8 12/31/03 ,
PSA 0.59. CEA 16.8, PAP 0.9 02/10/04
PSA 0.58, CEA 14.8. 03/28/04
Dx #9 Bone Scan: 04/26/04 When compared to the previous exam of 10/28/02, the increased
uptake in the right pelvis may be minimally more prominent. Progressive increased uptake are now noted at the L3-4 disc space. Small focal areas of increased uptake are now noted in the right pedicles of approximately T6 and T12. Degenerative changes are present in the cervical spine. An ill-defined area of increased uptake is noted in the region of the left mastoid air cells. This is unchanged from the prior exam.
PSA 0.74, CEA 17.8, PAP 1.1, NSE 8.6, CGA 5ng/ml. 04/27/04
PSA 0.86, CEA 20.6, PAP 1.2 06/15/04
PSA 1.18, CEA 22.9, PAP 1.5 08/02/04
Dx #10 Bone Scan 09/30/04 : When compared to the previous exam of 04/26/04 it is essentially unchanged.
09/30/04 PSA 1.11, CEA 22.8, PAP 1.5
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